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However, under increasing levels of OS in the CNS, ROS can impel aberrant signal transduction and activation of redox-regulated transcription factors, such as mitogen-activated protein kinases (MAPKs), nuclear factor- kappa B (NF-B) and activator protein 1 (AP-1), many of which play an essential role in inflammatory systems [40,41]

Glutathione is a small protein molecule called a tripeptide, made from three specific amino acids: cysteine, glycine, and glutamic acid

This process has approval (known as favourable opinion) from the South Central - Oxford B Research Ethics Committee, and support from the Health Research Authority (HRA) following advice from the Confidentiality Advisory Group (an independent body which provides expert advice on the use of confidential patient information)

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